Journal article
Functional immune changes are conserved in COVID-19 and trauma patients receiving intensive care.
Alexander JT Wood, Gesa J Albers, Willem Cornelissen, James D Maiden, Deirdre E Cuff, Mitra Ashayeripanah, Patrick Schriek, Samantha J Emery-Corbin, Nichollas E Scott, Shihan Li, Jan Schröder, Adam M Deane, Jose A Villadangos, Laura Cook
Nat Commun | Published : 2026
Abstract
Critical illness, including COVID-19 and trauma, induce immune dysregulation associated with morbidity and mortality. Direct comparison is crucial to identify shared pathobiological mechanisms to guide precision therapies. This prospective cohort study undertook a comprehensive, longitudinal comparison of innate immune cell function and plasma protein expression in critically ill patients at days 1, 3, and 5 of intensive care unit admission. We enrolled 26 COVID-19 patients, 20 trauma patients, and 18 healthy controls and analysed plasma proteins and immune cell phenotypes and responses to S. aureus bioparticles. An unsupervised multi-omics factor analysis (MOFA) identified shared sources of..
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